𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Molecular analysis of Hodgkin's disease-derived cell lines

✍ Scribed by Hans Tesch; Manfred Jücker; Martin H. Falk; Georg W. Bornkamm; David B. Jones; Volker Diehl

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
942 KB
Volume
6
Category
Article
ISSN
0278-0232

No coin nor oath required. For personal study only.

✦ Synopsis

Three Hodgkin's disease-derived cell lines were analysed for the organization of immunoglobulin and T cell receptor genes, for the expression of the interleukin 2 (IL-2) receptor gene, and for the cellular oncogene c-myc. All three cell lines have characteristic genotypic markers of lymphoid cells and can be classified as immature lymphoid cells with respect to the incomplete expression of their antigen receptor genes. This immature genotype is in contrast to the expression of activation antigens Ki-1 (CD 30), IL-2 receptor (CD 25), and HLA-DR. The results obtained are in agreement with studies obtained from primary Hodgkin's lymphomas, which are activated by as yet unknown mechanisms.

📜 SIMILAR VOLUMES

Production of multiple cytokines by Hodg
Production of multiple cytokines by Hodgkin's disease derived cell lines
✍ Dr S. Klein; M. Jucker; V. Diehl; H. Tesch 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English

## Abstract The production of cytokines was analysed in Hodgkin's disease (HD) derived cell lines by enzyme linked immunosorbent tests (ELISA) and Northern blot experiments. Our results demonstrate that HD derived cell lines produce a variety of cytokines, such as ILlα, IL4, IL5, IL6, IL8, TNFα, TN

In vitro differentiation of a hodgkin's
In vitro differentiation of a hodgkin's disease derived cell line
✍ S. Klein; D. B. Jones; Dr H. Tesch 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 535 KB

## Abstract We have examined the Hodgkin's disease derived cell line Co in terms of its capacity to differentiate __in vitro__. Co cells show the characteristics of immature T cells and express CD3 molecules in the cytoplasm. On activation with 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) these cells

Expression of SH2D1A in five classical H
Expression of SH2D1A in five classical Hodgkin's disease-derived cell lines
✍ Loránd L. Kis; Noémi Nagy; George Klein; Eva Klein 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 88 KB

The Src homology 2 domain protein 1A (SH2D1A) is a small, 128-amino acid protein consisting of a single SH2 domain; it is probably involved in signal regulation. It is expressed in activated T and natural killer (NK) cells, but not in B lymphocytes. It was discovered in studies on the rare hereditar

Identification of peanut agglutinin bind
Identification of peanut agglutinin binding glycoproteins restricted to Hodgkin's disease-derived cell lines
✍ D. J. Flavell; D. B. Jones; D. H. Wright 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 1023 KB

Peanut agglutinin (PNA) binding glycoproteins from four Hodgkin's desease (HD)-derived cell lines and a variety of cell lines/peripheral blood cells representative of the lymphoid and myeloid lineages were identified by probing nitrocellulose membranes of SDS-PAGE separated NP40 solubilized cellular

MOLECULAR ANALYSIS OF THENPM-ALK REARRAN
MOLECULAR ANALYSIS OF THENPM-ALK REARRANGEMENT IN HODGKIN'S DISEASE
✍ XERRI, LUC; PARC, PATRICIA; HASSOUN, JACQUES; BIRNBAUM, DANIEL 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 566 KB

The fusion gene NPM-ALK occurs in a subset of anaplastic large cell lymphomas (ALCLs), as a result of a chromosomal translocation, t(2;5) (p23;q35). It has been suggested that Hodgkin's disease (HD) and ALCL share a common histogenesis because of pathological and phenotypical similarities. In order

Characterization of the novel, pediatric
Characterization of the novel, pediatric Hodgkin disease-derived cell line HKB-1
✍ Wagner, H.J.; Klintworth, F.; Jabs, W.; Lange, K.; Schlegelberger, B.; Harder, L 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 623 KB

## Background. A novel Hodgkin disease (HD)-derived cell line, designated HKB-1, was established from pulmonary HD of nodular sclerosing subtype of a 14-year-old girl. Procedure and Results. Immunophenotypically, HKB-1 cells are of B cell in phenotype, being also positive for markers CD15, CD25 an