Cytogenetic abnormalities and leukemic transformation in hydroxyurea-treated patients with Philadelphia chromosome negative chronic myeloproliferative disease
✍ Scribed by Eva Löfvenberg; Ingrid Nordenson; Anders Wahlin
- Book ID
- 119104686
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 678 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0165-4608
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## Abstract ## BACKGROUND. Clonal cytogenetic abnormalities (CCA) were detected in Philadelphia chromosome (Ph)‐negative cells in some patients with chronic myeloid leukemia (CML) who attained a cytogenetic response to imatinib mesylate. In some patients, CCA/Ph‐negative status was associated with
## Abstract ## BACKGROUND Anecdotal cases of chromosomal abnormalities in Philadelphia chromosome (Ph)‐negative metaphases have been reported in patients with chronic myelogenous leukemia (CML) in the chronic phase during treatment with interferon and, more recently, with imatinib. This phenomenon