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Cytochrome P450-dependent toxic effects of primaquine on human erythrocytes

✍ Scribed by Shobana Ganesan; Babu L. Tekwani; Rajnish Sahu; Lalit M. Tripathi; Larry A. Walker

Book ID
113924588
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
462 KB
Volume
241
Category
Article
ISSN
0041-008X

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## Abstract The most prominent adverse effects seen during treatment with dapsone, an antibacterial and antiprotozoal agent, are hemolysis and methemoglobinemia. An __in vitro__ microsomal/cytochrome P~450~ (CYP)‐linked assay, which allows reactive metabolites generated __in situ__ to react with th