𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cytochrome P450 changes in rats with streptozocin-induced diabetes

✍ Scribed by Shimojo Nobuo


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
794 KB
Volume
26
Category
Article
ISSN
0020-711X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Modulation of the rat hepatic cytochrome
✍ Barnett, Christopher R. ;Flatt, Peter R. ;Ioannides, Costas πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 709 KB

The effects of long-term insulin-dependent diabetes on the enzymatic activities of hepatic cytochrome P450 isozymes were determined in rats rendered diabetic by the administration of streptozotocin and killed 4, 8, and 12 weeks following treatment. The 0-dealkylations of ethoxyresorufin and pentoxyr

Dimethylnitrosamine genotoxicity in rat
✍ TomΓ€s Mendoza-Figueroa πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 698 KB

Liver primary cell cultures (LPCC) with decreasing concentrations of cytochrome P-450 were used to investigate the genotoxicity of the hepatic carcinogen dimethylnitrosamine (DMN) and the correlation between DMN genotoxicity and cytochrome P-450 levels. Hepatocytes were isolated from partially hepat

Interaction of benzanthrone with cytochr
✍ Das, Mukul ;Garg, Kalpana ;Joshi, Anjulika ;Singh, Giriraj B. ;Khanna, Subhash K πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 783 KB

23%-34%), although the other enzyme, quinone reductase, which helps in the removal of toxic quinones, was found to be elevated (184%-199%). These results suggest several mechanisms by which benzanthrone may inhibit P450. This impairment of xenobiotic metabolism as well as the enhancement of lipid pe

Crucial role of cytochrome P450 in hepat
✍ Yasuhiro Ishihara; Satomi Ishii; Yufu Sakai; Nobue Yamamura; Yukiko Onishi; Nori πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 482 KB

## Abstract Quinone toxicity is induced by two principal mechanisms: arylation/alkylation and a redox cycle. We have previously shown that increases in intracellular levels of superoxide anion and cell death induced by 2,3‐dimethoxy‐1,4‐naphthoquinone (DMNQ), a redox cycling quinone, are enhanced b