✦ LIBER ✦

Interaction of benzanthrone with cytochrome p450: Altered patterns of hepatic xenobiotic metabolism in rats

✍ Scribed by Das, Mukul ;Garg, Kalpana ;Joshi, Anjulika ;Singh, Giriraj B. ;Khanna, Subhash K.

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 783 KB
Volume: 6
Category: Article
ISSN: 0887-2082
DOI: 10.1002/jbt.2570060106

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✦ Synopsis

23%-34%), although the other enzyme, quinone reductase, which helps in the removal of toxic quinones, was found to be elevated (184%-199%). These results suggest several mechanisms by which benzanthrone may inhibit P450. This impairment of xenobiotic metabolism as well as the enhancement of lipid peroxidation may be relevant to the observed symptoms of benzanthrone-induced hepatotoxicity.

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