Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes
β Scribed by Kyoung-Ah Kim; Ji-Young Park; Ji-Suk Lee; Sabina Lim
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 574 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0253-6269
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## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th