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Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes

✍ Scribed by Kyoung-Ah Kim; Ji-Young Park; Ji-Suk Lee; Sabina Lim


Publisher
Springer
Year
2003
Tongue
English
Weight
574 KB
Volume
26
Category
Article
ISSN
0253-6269

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## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th