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Cytochrome P450 2A-Catalyzed Metabolic Activation of Structurally Similar Carcinogenic Nitrosamines: N‘ -Nitrosonornicotine Enantiomers, N -Nitrosopiperidine, and N- Nitrosopyrrolidine

✍ Scribed by Wong, Hansen L.; Murphy, Sharon E.; Hecht, Stephen S.


Book ID
124049625
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
145 KB
Volume
18
Category
Article
ISSN
0893-228X

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✍ Anne-Marie Camus; Olivier Geneste; Paavo Honkakoski; Jean-Claude Béréziat; Colin 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 696 KB

## Abstract We undertook this study to answer several questions regarding nitrosamine metabolism. Kinetics of nitrosamine metabolism showed the involvement of at least two enzymes in the dealkylation of __N__‐nitrosodiethylamine (NDEA) and __N__‐nitrosodimethylamine (NDMA) in mouse liver microsomes