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Cytochalasin D abolishes the schistosomicidal activity of praziquantel

✍ Scribed by Livia Pica-Mattoccia; Cristiana Valle; Annalisa Basso; Anna Rita Troiani; Fabio Vigorosi; Piero Liberti; Alfredo Festucci; Donato Cioli

Book ID
113617365
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
408 KB
Volume
115
Category
Article
ISSN
0014-4894

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To profit from the concept of metabolite antagonism in the area of schistosomiasis chemotherapy, new compounds containing combinations of both substituted pyrimidine (closely related t o the pyrimidine moiety present in thiamine) and 5-nitrothiazole or 24midazolidinethione moieties were synthesized.