Cysteine endopeptidase activity levels in normal human tissues, colorectal adenomas and carcinomas

✍ Scribed by Sania Shuja; Kieran Sheahan; Mary Jo Murnane

• Book ID: 102869965
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: French
• Weight: 733 KB
• Volume: 49
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910490305

✦ Synopsis

We have assayed cysteine endopeptidase activities in I7 types of normal human tissue and in matched sets of colorectal mucosa, adenoma and carcinoma samples. Our data indicate that cathepsin B enzyme levels vary 70-fold and cathepsin L enzyme levels vary 20-fold from one normal tissue to another.

Cathepsin B specific activity in normal tissues fell into 3 cate ories. Hi h activity, with a mean of 156.7 * 4 I . 5 nmoles spleen; intermediate activity, with a mean of 60.2 k 8.3 nmoles rnin-' mg-' protein, was measured in heart, colon, adrenal and 4To whom reprint requests should be sent,