Cypridina bioluminescence I Sructure of cypridina luciferin
β Scribed by Toshito Kishi; Toshio Goto; Yoshimasa Hirata; Osamu Shimomura; Frank H. Johnson
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- French
- Weight
- 421 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
BIOLlEilNlSCENCE of Cypridina hilgendorfii (Japenese name:umi-hotaru) has been studied extensively since 1917, when Harvey (1) observed the luciferin-luciferase reaction with extracts of this animal. The luminescent system of Cypridina is one of the simplest among luminous animals and plantc 60 far investigated; only luciferin, luciferase and oxygen being required for the light production in aqueous solutions. Thss, it h&a been considered to be most suitable for the study of bio-li_:..;nescenoe mechanisms. General structures of the luciferin have been proposed by many workers (2), but since the materials used were impure, the evidence was not substantial. * * A paper under the same title is echeduled for publication in F. H.
π SIMILAR VOLUMES
CYPRIDINA luciferin (I) has been shoosn to have the structure represented by Ia (1). We wish to report in this oommunioation a total.
A total synthesis of Cypridina luciferin (I), a bioluminescent substance obtained from Cypridina hilgendorfii (l), was achieved in 1966 (2) by reductive condensation of an appropriate 2-aminopyrazine derivative and a-keto acid, but the yield was too low to use th!s route for preparative purposes. Tw
In a previous communication (Harvey and Tsuji, '55) me have reported that addition of the hydropcrosides of cumene, or tetralin, o r tertiary butyl t o luciferin dissolved in ethanol or in a trisolvent mixture will result in a lurninescencc readily visible to the dark adapted eye, provided oxygen is