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CYP3A5andNAT2gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome

✍ Scribed by Vanessa S. Silveira; Renata Canalle; Carlos Alberto Scrideli; Rosane G. P. Queiroz; Luiz Fernando Lopes; Luiz Gonzaga Tone

Book ID
113075182
Publisher
Springer
Year
2012
Tongue
English
Weight
226 KB
Volume
364
Category
Article
ISSN
0300-8177

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## Abstract Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The genetic factors underlying the susceptibility to this disease remain elusive. The enzymes CYP2E1, MPO and NQO1 are involved in the biotransformation of a variety of xenobiotics present in organic solvents, tobac