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CYP2C9 Structure−Metabolism Relationships: Optimizing the Metabolic Stability of COX-2 Inhibitors

✍ Scribed by Ahlström, Marie M.; Ridderström, Marianne; Zamora, Ismael; Luthman, Kristina

Book ID
120364957
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
179 KB
Volume
50
Category
Article
ISSN
0022-2623

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## Structure-activity relationship Computer-assisted molecular modeling Free energy perturbation Metabolic stability a b s t r a c t Combination of the structure-based design and solid-phase parallel synthesis provided an integrated approach to rapidly develop the structure-activity relationship o