CYP17gene polymorphism in relation to breast cancer risk: a case-control study
✍ Scribed by Kristjana Einarsdóttir, Tove Rylander-Rudqvist, Keith Humphreys…
- Book ID
- 120700029
- Publisher
- BioMed Central
- Year
- 2005
- Tongue
- English
- Weight
- 160 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr1319
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Long-term exposure to oestrogens is a well-recognised risk factor for breast cancer, whereas little is known about the influence of polymorphisms of genes involved in oestrogen biosynthesis and metabolism. A candidate, containing a single bp polymorphism, T8C, (designated, A2 allele), might be the C
CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog