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CYP17 polymorphism (rs743572) is associated with increased risk of gallbladder cancer in tobacco users

✍ Scribed by Rai, Rajani; Sharma, Kiran L.; Misra, Sanjeev; Kumar, Ashok; Mittal, Balraj


Book ID
121825596
Publisher
S. Karger AG
Year
2014
Tongue
English
Weight
981 KB
Volume
35
Category
Article
ISSN
1010-4283

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A polymorphism in the CYP17 gene is asso
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CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog