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CYP17 gene promoter allelic variant is not associated with prostate cancer

✍ Scribed by Cheng-Chieh Lin; Hsi-Chin Wu; Wen-Chi Chen; Huey-Yi Chen; Fuu-Jen Tsai

Book ID
117724244
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
54 KB
Volume
21
Category
Article
ISSN
1078-1439

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CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog