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Cyclosporine nephrotoxicity: the mechanisms of cell injury by cyclosporine A in renal proximal tubular cells

✍ Scribed by S.I Kim; H.Y Song; J.H Hwang; D.L Chong; H.Y Lee; D.S Han; J.I Moon; Y.S Kim; K.I Park; K.S Kim; K.H Choi

Book ID
117229519
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
97 KB
Volume
32
Category
Article
ISSN
0041-1345

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## Abstract Cyclosporine A (CsA) is known to have direct toxicity to renal tubular cells. Its toxicity may be mediated by intracellular calcium because CsA increases intracellular calcium concentration and enhances the activities of calcium‐dependent calpains and caspases. Calbindin‐D~28k~, a cytos