Hyperammonemia is a rare and serious complication of intensive cytotoxic chemotherapy. We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate,
Cyclosporin associated demyelination following allogeneic bone marrow transplantation
โ Scribed by Dr. M. J. Lind; L. McWilliam; J. Jip; J. H. Scarffe; G. R. Morgenstern; J. Chang
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 252 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0278-0232
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โฆ Synopsis
Neurological complications associated with cyclosporin administration are well documented. However their histopathological basis are ill-understood. We describe below a case of demyelination following cyclosporin administration to a patient following allogeneic bone marrow transplantation.
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In order to study the posttransplant evolution of serum immunoglobulin levels, we measured serum IgG, IgA and IgM levels in 50 recipients of allogeneic bone marrow before transplantation and at different intervals thereafter (days 39, 120, 365 and 730). IgG and IgM levels were depressed for 1 year a
Graft versus host disease is a major barrier in allogeneic bone marrow transplantation. The associated morbidity and mortality need to be understood and prevented if possible, as the potential indications for bone marrow transplantation continue to broaden. Areas of investigation include the cellula