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Hyperammonemia following allogeneic bone marrow transplantation

✍ Scribed by Nielson Tse; Stephen Cederbaum; John A. Glaspy

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
181 KB
Volume
38
Category
Article
ISSN
0361-8609

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✦ Synopsis

Hyperammonemia is a rare and serious complication of intensive cytotoxic chemotherapy. We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate, and the experimental agent sodium phenylacetate, the patient ultimately succumbed to complications of this metabolic derangement. The literature is reviewed, and recommendations for an approach to this complication of marrow transplantation are proposed.

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