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Cyclopropane-Annelated Azaoligoheterocycles by Ti-Mediated Intramolecular Reductive Cyclopropanation of Cyclic Amino Acid Amides

✍ Scribed by Martina Gensini; Armin de Meijere


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
157 KB
Volume
10
Category
Article
ISSN
0947-6539

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A variety of tris-and monoprotected derivatives with the 1amino-3-azabicyclo[3.1.0]hexane and 1-amino-3-azabicyclo[4.1.0]heptane skeleton 10 have been synthesized by intramolecular reductive cyclopropanation of α-(N-allylamino)substituted N,N-dialkylcarboxamides 6, 8, and 9. Starting from derivative