3-Azabicyclo[3.1.0]hex-1-ylamines by Ti-Mediated Intramolecular Reductive Cyclopropanation of α-(N-Allylamino)-Substituted N,N-Dialkylcarboxamides and Carbonitriles.

3-Azabicyclo[3.1.0]hex-1-ylamines by Ti-

3-Azabicyclo[3.1.0]hex-1-ylamines by Ti-Mediated Intramolecular Reductive Cyclopropanation of α-(N-Allylamino)-Substituted N,N-Dialkylcarboxamides and Carbonitriles

✍ Martina Gensini; Sergei I. Kozhushkov; Dmitrii S. Yufit; Judith A. K. Howard; Ma 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 217 KB

A variety of tris-and monoprotected derivatives with the 1amino-3-azabicyclo[3.1.0]hexane and 1-amino-3-azabicyclo[4.1.0]heptane skeleton 10 have been synthesized by intramolecular reductive cyclopropanation of α-(N-allylamino)substituted N,N-dialkylcarboxamides 6, 8, and 9. Starting from derivative