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Cyclophosphamide enhances the immunosuppressive action of its own active metabolites

โœ Scribed by L. Yu. Telegin; V. M. Pisarev; L. A. Pevnitsky

Book ID
110159504
Publisher
Springer
Year
2008
Tongue
English
Weight
108 KB
Volume
423
Category
Article
ISSN
0012-4966

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Cyclophosphamide (CPA), the most commonly used alkylating agent in the treatment of a wide variety of hematologic and solid tumors, requires oxidation by hepatic microsomal enzymes to its active alkylating species. A number of alternative methods exist to simulate the in vitro cytotoxicity of CPA ag