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Cyclophilin: a specific cytosolic binding protein for cyclosporin A

✍ Scribed by Handschumacher, R.; Harding, M.; Rice, J; Drugge, R.; Speicher, D.


Book ID
111679022
Publisher
American Association for the Advancement of Science
Year
1984
Tongue
English
Weight
1002 KB
Volume
226
Category
Article
ISSN
0036-8075

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Human cyclophilin A (hCypA) contains one tryptophan residue at position 121 (Trp121). The fluorescence intensity of this single tryptophan residue doubles upon binding the clinically important immunosuppressant cyclosporin A (CsA). Trp121 is in close contact to the bound CsA and is well-conserved in