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Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions

✍ Scribed by Giulio Maria Pasinetti

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 57 KB
Volume: 54
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19981001)54:1<1::aid-jnr1>3.0.co;2-m

No coin nor oath required. For personal study only.

✦ Synopsis

Many epidemiological studies suggest that use of non-steroidal anti-inflammatory drugs (NSAIDs) delay or slow the clinical expression of Alzheimer's disease (AD). While it has been demonstrated that neurodegeneration in AD is accompanied by specific inflammatory mechanisms, including activation of the complement cascade and the accumulation and activation of microglia, the mechanism by which NSAIDs might affect these or other pathophysiological processes relevant to AD has been unclear. New evidence that cyclooxygenase (COX) is involved in neurodegeneration along with the development of selective COX inhibitors has led to renewed interest in the therapeutic potential of NSAIDs in AD.

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