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Cyclooxygenase-2, Player or Spectator in Cyclooxygenase-2 Inhibitor-Induced Apoptosis in Prostate Cancer Cells

✍ Scribed by Song, X.

Book ID: 125538926
Publisher: Oxford University Press
Year: 2002
Tongue: English
Weight: 187 KB
Volume: 94
Category: Article
ISSN: 0027-8874
DOI: 10.1093/jnci/94.8.585

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## Abstract Many tumors constitutively express high levels of the inducible form of proinflammatory enzyme, cyclooxygenase‐2 (COX‐2). Increased COX‐2 expression is associated with tumor cell resistance to many cytotoxic chemotherapy drugs. Furthermore, increased resistance to cytotoxic antitumor dr