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Cyclooxygenase-2 over-expression inhibits liver apoptosis induced by hyperglycemia

✍ Scribed by Francés, Daniel E.A.; Ingaramo, Paola I.; Mayoral, Rafael; Través, Paqui; Casado, Marta; Valverde, Ángela M.; Martín-Sanz, Paloma; Carnovale, Cristina E.

Book ID
118762571
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
482 KB
Volume
114
Category
Article
ISSN
0730-2312

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## Cyclooxygenase -2 (COX-2) is upregulated in many cancers, and the prostanoids synthesized increase proliferation, improve angiogenesis, and inhibit apoptosis in several tissues. To explore the function of COX-2 in liver, transgenic (Tg) mice were generated containing a fusion gene (LIVhCOX-2) c