𝔖 Bobbio Scriptorium
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Cyclooctadepsipeptides – a new class of anthelmintically active compounds

✍ Scribed by Achim Harder; Georg von Samson-Himmelstjerna


Book ID
106126272
Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
167 KB
Volume
88
Category
Article
ISSN
1432-1955

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PF 1022A, a 24-membered cyclooctadepsipeptide and a potent anthelmintic drug, is active against nematodes but not against arthropods. Muscle cells of Ascaris suum generate autorhythmic spikes in electrophysiological control experiments. Exposure of the worm to PF 1022A leads to flaccid paralysis and