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Cyclodextrins as chiral selectors in capillary electrophoresis: A comparative study for the enantiomeric separation of some beta-agonists

✍ Scribed by Hassan Y. Aboul-Enein; Mihnea D. Efstatiade; George E. Baiulescu

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 90 KB
Volume: 20
Category: Article
ISSN: 0173-0835
DOI: 10.1002/(sici)1522-2683(19990901)20:13<2686::aid-elps2686>3.0.co;2-0

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✦ Synopsis

Cyclodextrins as chiral selectors in capillary electrophoresis: A comparative study for the enantiomeric separation of some beta-agonists A comparative study for the enantiomeric separation of terbutaline, clenbuterol, salbutamol and dobutamine was performed by capillary electrophoresis using cyclodextrins and their derivatives as chiral selectors. Several parameters such as buffer composition and temperature were studied. Simple, fast and reliable enantioseparations were achieved for all drugs studied, especially when the isomerically pure sulfated b-cyclodextrin derivatives were used as chiral selectors.

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