๐”– Bobbio Scriptorium
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Cycloadditions of 4-oxazolin-2-ones

โœ Scribed by J.A. Deyrup; H.L. Gingrich


Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
151 KB
Volume
18
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


The B-amino alcohol structural unit is a key component of many important natural and synthetic substances.


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3-Nosyloxy-2-ketoesters, available from 2-ketoesters, react efficiently with methyl carbamate and tosic acid in refluxing toluene to provide 4-carboalkoxy-4oxazolin-2-ones in good yields (41-84%).

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Reaction of 4-Substituted Aminomethylene-2-phenyl-2-oxazolin-5-ones with Primary Amines. -Reaction of the title 4aminomethyleneoxazolinones (I) with primary alkyl amines in MeCN provides regioselectively the transamination products (III) in excellent yields. Similar aminolysis with primary aryl ami