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Cyclization reactions of 4-(3′-butenyl)azetidin-2-one a route to the carbopenam ring system

✍ Scribed by Tetsuo Aida; Richard Legault; Denise Dugat; Tony Durst

Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
146 KB
Volume
20
Category
Article
ISSN
0040-4039

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✦ Synopsis

Cyclization of 4-(3'-butenyl)azetidin-2-one, 2 initiated by electrophilic reagents such as 12, Hg(OAc)2 results in the formation of bicyclic B-lactams having the carbopenam ring skeleton. Reaction of gwith Br2 results in simple addition of Br2 to the double bond, while PhSBr gives a mixture of cyclization and addition products.

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