Enantioselective synthesis of the nagila
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Steven D. Burke; Sharon M.S. Strickland; Helen M. Organ; Louis A. Silks III
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Article
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1989
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Elsevier Science
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French
β 238 KB
The functionalized tricyclic nagilactone precursor 19 was synthesized by a route featuring a vinylsilane terminated/1,3-dioxane acetal initiated bicyclization. Relative and absolute stereochemical control were achieved via the optically active pentenolide template 14.