Cyclization of acetylenylpyrazolecarboxylic acids
β Scribed by M. S. Shvartsberg; S. F. Vasilevskii; T. V. Anisimova; V. A. Gerasimov
- Book ID
- 112443369
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 379 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1573-9171
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## Abstract We report a new and efficient methodology to prepare __N__βamino pyrazolo[4,3β__c__]pyridinβ4βones **4** and __N__βamino pyrazolo[3,4β__c__]pyridinβ4βones **8** from __vic__βacetylenyl/hydrazido pyrazoles. The procedure involves the intermediate synthesis of methyl esters of acetylenylβ
plished with the system propionic acid/water/carbon tetrachloride in a flow apparatus specially developed for this purpose [21. The resulting kinetic data are plausible if the boundary layer reaction occurring on transfer of a caroxylic acid is formulated as a series of three individual reaction ste