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Study of the heterocyclization of vic-substituted hydrazides of acetylenylpyrazolecarboxylic acids into N-amino pyrazolopyridinones

✍ Scribed by Sergei F. Vasilevsky; Elena V. Mshvidobadze; José Elguero

Book ID: 102339934
Publisher: Journal of Heterocyclic Chemistry
Year: 2002
Tongue: English
Weight: 52 KB
Volume: 39
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570390617

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✦ Synopsis

Abstract

We report a new and efficient methodology to prepare N‐amino pyrazolo[4,3‐c]pyridin‐4‐ones 4 and N‐amino pyrazolo[3,4‐c]pyridin‐4‐ones 8 from vic‐acetylenyl/hydrazido pyrazoles. The procedure involves the intermediate synthesis of methyl esters of acetylenyl‐pyrazole carboxylic acids and the subsequent cyclization under a variety of conditions.

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