Cyclisation of Aminyl Radicals Derived from Amino Acids
β Scribed by W.Russell Bowman; Michael J Broadhurst; Daniel R Coghlan; Kirk A Lewis
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 628 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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The use of copper complexes in the protection of lysine and tyrosine side chains has been extensively described. Based on this work and in order to produce a peptide library consisting of unnatural amino acids, three amino acids were prepared by acylation/sulfonation of the ~i-amino function of orni
Radical cycliitions of various methylenecycbpopane derivatives have been stdied and it has been fotmd that methylenecyc~l pfopyl radicals undergo exclusive 5-cx0 cydhtion while methylenecycloppyl butyl mdicala give a mixtme of product9 resulting tium f&x0 and 7-efdo cyclisation. Attempted cyclisatio