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Cyclin kinase inhibitor p21 potentiates bile acid–induced apoptosis in hepatocytes that is dependent on p53

✍ Scribed by Liang Qiao; Robert McKinstry; Seema Gupta; Donna Gilfor; Jolene J. Windle; Philip B. Hylemon; Steven Grant; Paul B. Fisher; Paul Dent


Book ID
111721888
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
299 KB
Volume
36
Category
Article
ISSN
0270-9139

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## Abstract Betel‐quid use is associated with liver cancer whereas its constituent arecoline is cytotoxic, genotoxic, and induces p53‐dependent p21^WAF1^ protein expression in Clone‐9 cells (rat hepatocytes). The ataxia telangiectasia mutated (ATM)/rad3‐related (ATR)‐p53‐p21^WAF1^ and the phosphati