Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells
β Scribed by Dennis W Stacey
- Book ID
- 114309448
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 186 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0955-0674
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An important positive regulator of the cell cycle, cyclin D1, is often amplified and overexpressed in malignancies. Cyclin D1 aberrations were analysed in grade II-IV astrocytomas by fluorescence in situ hybridization (FISH), mRNA in situ hybridization and immunohistochemistry. Proliferation activit