## Background and Objectives: The goal was to evaluate the clinicopathological significance of retinoblastoma gene product (pRB) expression in esophageal squamous cell carcinoma. Methods: We investigated abnormal pRB expression in tumors in 191 patients using an immunohistochemical method in conjun
Cyclin D1 expression and retinoblastoma gene protein (pRB) expression in esophageal squamous cell carcinoma
β Scribed by Masahide Ikeguchi; Takashi Sakatani; Tsuyoshi Ueta; Nobuaki Kaibara
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 90 KB
- Volume
- 127
- Category
- Article
- ISSN
- 1432-1335
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The retinoblastoma gene (RB) is a typical tumor-suppressor gene. Inactivation of RB has been shown in a variety of human cancers, including esophageal squamous-cell carcinomas. In the present study, samples of normal esophageal squamous epithelium (n β«Ψβ¬ 10), severe squamous-cell dysplasias (n β«Ψβ¬ 1
Cyclin-D1 over-expression represents one of several common alterations in the G 1 -S transition associated with malignancies. Conclusive evidences indicate that cyclin D1 is a proto-oncogene and the gene is amplified or rearranged in different tumour types. Since very little is known about aberratio
There have been few reports on genetic alterations in thymomas. To investigate the expression of p16 INK4A , RB, p53 and cyclin D1 in thymomas, we first examined 36 thymomas (non-invasive type, 16 cases; invasive type, 20 cases) and 3 thymic carcinomas, using immunohistochemistry. Abnormal expressio