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Cyclic variations in sensitivity to X-irradiation during meiosis in Saccharomyces cerevisiae

✍ Scribed by Kelly, S. L. ;Merrill, C. ;Parry, J. M.

Publisher
Springer
Year
1983
Tongue
English
Weight
555 KB
Volume
191
Category
Article
ISSN
0026-8925

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✦ Synopsis

Cyclic variation in mutation induction and lethality was found following X-irradiation during meiosis in Saccharomyces cerevisiae. An enhanced mutagenic response was found in meiotic G1 phase cells in comparison to cells later in meiosis, similar to the response shown during mitosis, but meiotic G1 phase cells appeared more resistant to the lethal effects of X-irradiation than mitotic G1 phase cells. Resistance to the lethal effects of X-rays was found during meiotic DNA synthesis in the strain SK1, which may indicate the operation of a sister-chromatid exchange repair mechanism. A difference was found between gene conversion which appeared to be at a maximum by the end of meiotic DNA synthesis and reciprocal recombination, which could be induced up to prophase I.

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DNA degradation and reduced recombination following UV irradiation during meiosis in yeast (Saccharomyces cerevisiae)
✍ Salts, Yehiam ;Simchen, Giora ;PiοΏ½on, Ramon πŸ“‚ Article πŸ“… 1976 πŸ› Springer 🌐 English βš– 460 KB

Irradiation of meiotic yeast cells with moderate doses of ultraviolet irradiation (1,600 erg/mm2) leads to the arrest of premeiotic DNA synthesis, massive (5-40%) DNA degradation, and a 40-50% loss of cell viability. In contrast, such doses of UV irradiation had a minor effect on viability (15-20% l