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Cyclic Ureas, III: On the Metabolism of the Enantiomers of Cyclic Ureas in Rats

✍ Scribed by Hans H. Maurer; Joachim Biwersi; Joachim Knabe

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
271 KB
Volume
326
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

Studies are described on the metabolism of the enantiomers of 1, 2, and 3 in rats. The metabolites were identified in urine after cleavage of conjugates and extraction using gas chromatography‐mass spectrometry. Qualitative enantioselective differences of the metabolism of 1, 2, and 3 could not be detected. Because oxidation of 1 and 2 to the corresponding barbiturates could not be found and 3 was oxidized to mephenytoin only in minor amounts, this pathway is not a prerequisite for the sedative‐hypnotic effects of 1, 2, and 3.

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