Cyclic Peptide Design

✍ Scribed by Gilles Goetz

Publisher: Springer New York; Humana
Year: 2019
Tongue: English
Leaves: 332
Series: Methods in Molecular Biology 2001
Edition: 1st ed.
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature’s cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field.
Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields.

✦ Table of Contents

Front Matter ....Pages i-x
Design Principles for Intestinal Permeability of Cyclic Peptides (Alan M. Mathiowetz)....Pages 1-15
Strategies to Enhance Metabolic Stabilities (Bhavesh Khatri, Venkateswara Rao Nuthakki, Jayanta Chatterjee)....Pages 17-40
Designing Cell-Permeable Macrocyclic Peptides (George Appiah Kubi, Patrick G. Dougherty, Dehua Pei)....Pages 41-59
Computational Methods for Studying Conformational Behaviors of Cyclic Peptides (Fan Jiang, Hao Geng)....Pages 61-71
Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein–Protein Interactions (Fergal Duffy, Nikunj Maheshwari, Nicolae-Viorel Buchete, Denis Shields)....Pages 73-95
Design of Cyclic Peptides as Protein Recognition Motifs (Ye Che)....Pages 97-106
Design and Synthetic Strategies for Helical Peptides (Licheng Tu, Dongyuan Wang, Zigang Li)....Pages 107-131
Click Chemistry for Cyclic Peptide Drug Design (Adel Ahmed Rashad)....Pages 133-145
Frontier Between Cyclic Peptides and Macrocycles (Philipp Ermert, Anatol Luther, Peter Zbinden, Daniel Obrecht)....Pages 147-202
Building upon Nature’s Framework: Overview of Key Strategies Toward Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles (Maria-Jesus Blanco)....Pages 203-233
Design of Oxytocin Analogs (Kazimierz Wiśniewski)....Pages 235-271
DNA-Encoded Macrocyclic Peptide Library (Zhengrong Zhu, Alex Shaginian, La Shadric C. Grady, Christopher P. Davie, Kenneth Lind, Sandeep Pal et al.)....Pages 273-284
Peptide Display Technologies (Anthony Pitt, Zeke Nims)....Pages 285-298
Discovery of Functional Macrocyclic Peptides by Means of the RaPID System (Christos Tsiamantas, Manuel E. Otero-Ramirez, Hiroaki Suga)....Pages 299-315
Genetic Selections with SICLOPPS Libraries: Toward the Identification of Novel Protein–Protein Interaction Inhibitors and Chemical Tools (Francisco Castillo, Ali Tavassoli)....Pages 317-328
Back Matter ....Pages 329-332

✦ Subjects

Biomedicine; Pharmaceutical Sciences/Technology; Biochemistry, general; Cell Physiology

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