Cyclic nucleotides phosphodiesterase activity changes in early chick development
β Scribed by T. Neuman
- Book ID
- 105415164
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 241 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1420-682X
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π SIMILAR VOLUMES
We investigated the level and characteristics of ''low Km'' 3'-5' cyclic nucleotide phosphodiesterase (PDE) activity in adult and embryo chick spinal cord. The DEAE cellulose chromatography elution profile of Triton X-100 extracts showed a single peak of calmodulin-dependent cAMP/cGMP PDE activity.
Erythrocyte soluble phosphodiesterase activities show at least two interconvertible states: "aggregated' and "non-aggregated'. In the former state the existence of a high affinity component for cyclic AMP is favoured and the system is more active with cyclic AMP than with cyclic GMP as substrate. Wh