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Cyclic hydrostatic pressure and particles increase synthesis of 1,25-dihydroxyvitamin D3 by human macrophages in vitro

✍ Scribed by C.E. Evans; S. Mylchreest; A.P. Mee; J.L. Berry; J.G. Andrew


Book ID
116307192
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
296 KB
Volume
38
Category
Article
ISSN
1357-2725

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Cultured microglial cells were examined for their ability to metabolize 25-hydroxyvitamin D, (25-(OH) D,). Upon exposure to lipopolysaccharide, microglial cells produced a vitamin D metabolite which comigrated with synthetic 1,25-dihydroxyvitamin D, (1,25-(OH),D,) in two different systems of high pe