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Cyclic HIV Protease Inhibitors: Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas

✍ Scribed by Lam, Patrick Y. S.; Ru, Yu; Jadhav, Prabhakar K.; Aldrich, Paul E.; DeLucca, George V.; Eyermann, Charles J.; Chang, Chong-Hwan; Emmett, George; Holler, Edward R.; Daneker, Wayne F.; Li, Liangzhu; Confalone, Pat N.; McHugh, Robert J.; Han, Qi; Li, Renhua; Markwalder, Jay A.; Seitz, Steven P.; Sharpe, Thomas R.; Bacheler, Lee T.; Rayner, Marlene M.; Klabe, Ronald M.; Shum, Linyee; Winslow, Dean L.; Kornhauser, David M.; Jackson, David A.; Erickson-Viitanen, Susan; Hodge, C. Nicholas


Book ID
120254992
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
424 KB
Volume
39
Category
Article
ISSN
0022-2623

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ChemInform Abstract: HIV Protease Inhibi
✍ W. W. WILKERSON; E. AKAMIKE; W. W. CHEATHAM; A. Y. HOLLIS; R. D. COLLINS; I. DEL 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

HIV Protease Inhibitory Bis-benzamide Cyclic Ureas: A Quantitative Structure-Activity Relationship Analysis. -A series of about thirty title compounds, such as (V), is synthesized and evaluated for HIV protease inhibition and antiviral activity. Derivatives (V) show to be potent inhibitors of HIV p