Cyclic ADP-Ribose and NAADP: Structures, Metabolism and Functions

✍ Scribed by Hon Cheung Lee (auth.), Hon Cheung Lee (eds.)

• Publisher: Springer US
• Year: 2002
• Tongue: English
• Leaves: 461
• Edition: 1
• Category: Library

✦ Synopsis

In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. This is the first book devoted entirely to the field. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the current methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signaling mechanisms and specific physiological functions of these two messengers in various cellular systems.

✦ Table of Contents

Front Matter....Pages I-XVIII
Cyclic ADP-Ribose and NAADP....Pages 1-21
ADP-Ribosyl Cyclases - A Family of cADPR and NAADP Metabolizing Enzymes....Pages 23-43
Regulation of Synthesis of cADPR and NAADP....Pages 45-64
A Natural History of the Human CD38 Gene....Pages 65-79
A Yeast Expression System of High Efficiency for Producing Recombinant Enzymes....Pages 81-99
Novel Cycling Assays for cADPR and NAADP....Pages 101-120
Pharmacology of Cyclic ADP-Ribose and NAADP....Pages 121-142
Separate but Interacting Calcium Stores....Pages 143-166
Sensitizing Calcium-Induced Calcium Release....Pages 167-197
Spatial and Temporal Control of Calcium Signaling by NAADP....Pages 199-215
Regulation of Immune Responses by CD38 and cADPR....Pages 217-240
Subcellular and Extracellular Trafficking of NAD + and Cyclic ADP-Ribose: A New Way for Regulating Intracellular Calcium Homeostasis....Pages 241-267
The CD38-Cyclic ADP-Ribose Signal System in Pancreatic ß-Cells....Pages 269-299
The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation....Pages 301-318
Calcium Signaling by cADPR in Cardiac Myocytes....Pages 319-341
Cyclic ADP-Ribose and Vasomotor Response....Pages 343-363
Coordination of Calcium Signaling by cADPR and NAADP in Pancreatic Acinar Cells....Pages 365-379
Calcium and Calcium-Linked Second Messengers are Main Actors in the Maturation and Fertilization of Starfish Oocytes....Pages 381-396
ADP-Ribosylation and CD38 Signaling....Pages 397-407
Retinoid-Mediated Signaling and CD38 Expression....Pages 409-425
Calcium Regulation in Smooth Muscle Through the CD38/Cyclic ADP-Ribose Pathway....Pages 427-449
Back Matter....Pages 451-460

✦ Subjects

Pharmacology/Toxicology; Biochemistry, general