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CV6209 inhibits airway wall thickening and airway hyperresponsiveness to histamine induced by intravenous administration of platelet-activating factor in guinea pigs

✍ Scribed by Motohiro Kurosawa; Hideo Tsukagoshi; Yasushi Igarashi; Yoshiki Miyachi


Book ID
116163469
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
830 KB
Volume
13
Category
Article
ISSN
0929-7855

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SUMMARY: We studied the effect of iv administration of leukotriene (LT) \(\mathrm{C}_{4}\) on bronchial responsiveness to histamine and airway wall thickening in guinea-pigs. The infusion of \(3 \mu \mathrm{g} / \mathrm{kg} \mathrm{LTC}\) for \(1 \mathrm{~h}\) induced an increase of the relative thi