Inhibition by thromboxane antagonists of airway hyperresponsiveness to histamine induced by 13,14-dihydro-15-keto-PGF2α in guinea-pigs

Inhibitory Effect of a Thromboxane A2 Sy

Inhibitory Effect of a Thromboxane A2 Synthetase Inhibitor OKY-046 on Bronchial Hyperresponsiveness to Histamine, but not on Airway Wall Thickening, Induced by Intravenous Administration of Leukotriene C4 in Guinea-pigs

✍ M. Kurosawa; H. Tsukagoshi 📂 Article 📅 1993 🏛 Elsevier 🌐 English ⚖ 350 KB

SUMMARY: We studied the effect of iv administration of leukotriene (LT) \(\mathrm{C}_{4}\) on bronchial responsiveness to histamine and airway wall thickening in guinea-pigs. The infusion of \(3 \mu \mathrm{g} / \mathrm{kg} \mathrm{LTC}\) for \(1 \mathrm{~h}\) induced an increase of the relative thi