✦ LIBER ✦

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

✍ Scribed by Ohashi, K.; Burkart, V.; Flohe, S.; Kolb, H.

Book ID: 124169905
Publisher: American Association of Immunologists
Year: 2000
Tongue: English
Weight: 295 KB
Volume: 164
Category: Article
ISSN: 0022-1767
DOI: 10.4049/jimmunol.164.2.558

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Human heat shock protein 60 (hsp60) elicits a potent proinflammatory response in cells of the innate immune system and therefore has been proposed as a danger signal of stressed or damaged cells. We report here that macrophages of C3H/HeJ mice, carrying a mutant Toll-like-receptor (Tlr) 4 are nonresponsive to hsp60. Both the induction of TNF-α and NO formation were found dependent on a functional Tlr4 whereas stimulation of macrophages by CpG DNA was Tlr4 independent. We conclude that Tlr4 mediates hsp60 signaling. This is the first report of a putative endogenous ligand of the Tlr4 complex.

📜 SIMILAR VOLUMES

Cutting Edge: Heat Shock Protein 60 Is a

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

✍ Ohashi, K.; Burkart, V.; Flohe, S.; Kolb, H. 📂 Article 📅 2000 🏛 American Association of Immunologists 🌐 English ⚖ 295 KB

P130 Heat shock protein 60 and toll like

P130 Heat shock protein 60 and toll like receptor 4 as an endogenous activator complex of microglia in Parkinson disease

✍ C. Noelker; L. Morel; D. Alvarez-Fischer; A. Osterloh; T. Lescot; M. Breloer; C. 📂 Article 📅 2011 🏛 Elsevier 🌐 English ⚖ 38 KB

Immunolocalization of Toll-Like Receptor

Immunolocalization of Toll-Like Receptors 2 and 4 as well as Their Endogenous Ligand, Heat Shock Protein 70, in Rat Traumatic Brain Injury

✍ Zhang, Zhiren; Zhang, Zhi-Yuan; Wu, Yuzhang; Schluesener, Hermann J. 📂 Article 📅 2012 🏛 S. Karger AG 🌐 English ⚖ 693 KB

A Vicious Cycle Involving Release of Hea

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

✍ Lehnardt, S.; Schott, E.; Trimbuch, T.; Laubisch, D.; Krueger, C.; Wulczyn, G.; 📂 Article 📅 2008 🏛 Society for Neuroscience 🌐 English ⚖ 756 KB

PL7. Heat Shock Protein 70 (HSP70) Serve

PL7. Heat Shock Protein 70 (HSP70) Serves as an Endogenous Inhibitor of Toll-Like Receptor 4 (TLR4) Signaling During Enterocyte Apoptosis in the Pathogenesis of Necrotizing Enterocolitis

✍ A. Afrazi; S.C. Gribar; W.M. Richardson; T. Prindle Jr.; M.F. Branca; C. Sodhi; 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 253 KB

Toll-like receptor (TLR) 2 and 6 ligands

Toll-like receptor (TLR) 2 and 6 ligands and heat shock proteins 60 and 70 may play a role in the pathogenesis of skeletal muscle damage in critical limb ischaemia

✍ Patel, Hemanshu; Navi, Ali; Shi-wen, Xu; Abraham, David; Baker, Daryll; Shaw, Si 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 58 KB