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Current status of phthalocyanines in the photodynamic therapy of cancer

✍ Scribed by Cynthia M. Allen; Wesley M. Sharman; Johan E. Van Lier

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
101 KB
Volume
05
Category
Article
ISSN
1088-4246

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✦ Synopsis

Photodynamic therapy is a binary treatment now accepted in clinic for various malignancies in several countries around the world. Phthalocyanine molecules are second-generation photosensitizers with enhanced photophysical and photochemical properties over those of porphyrins. They have been shown to be phototoxic against a number of cell types and tumor models. A great deal of research has been devoted to the elucidation of their mechanism of action and mode of cell death. The present paper reviews phthalocyanine pre-clinical anti-cancer research with emphasis on phthalocyanine induced apoptosis using a silicon phthalocyanine, Pc 4. A brief summary of the latest clinical results using phthalocyanines is presented.

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