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Current Protocols in Nucleic Acid Chemistry || Synthesis of Acyclic Nucleoside Phosphonates

✍ Scribed by Beaucage, Serge L.; Bergstrom, Donald E.; Glick, Gary D.; Jones, Roger A.

Book ID
120506064
Publisher
Wiley (John Wiley & Sons)
Year
2005
Tongue
English
Weight
411 KB
Volume
22
Category
Article
ISBN-13
9780471142706
ISSN
1934-9270

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Synthesis of acyclic nucleoside phosphon
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## Abstract Reaction of 6‐chloropyrimidines with diethyl [(2‐aminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5‐substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (