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Current Protocols in Human Genetics || Detection of Mutations by Denaturing Gradient Gel Electrophoresis

โœ Scribed by Haines, Jonathan L.; Korf, Bruce R.; Morton, Cynthia C.; Seidman, Christine E.; Seidman, J.G.; Smith, Douglas R.

Book ID
121866633
Publisher
Wiley (John Wiley & Sons)
Year
1998
Tongue
English
Weight
237 KB
Volume
17
Category
Article
ISBN
0471142905
ISSN
1934-8266

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Detecting prion protein gene mutations b
Detecting prion protein gene mutations by denaturing gradient gel electrophoresis
โœ John K. Fink; Michael L. Peacock; James T. Warren Jr.; Allen D. Roses; Stanley B ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 844 KB

Mutations of the prion protein (PrP) gene are present in patients with Gerstmann-Straussler-Scheinker syndrome (GSS), familial Creutzfeldt-Jakob disease (CJD), and fatal familial insomnia (FFI). We developed a denaturing gradient gel electrophoresis (DGGE) strategy that readily identifies point muta