## BACKGROUND. Because tumors require angiogenesis for growth, inhibiting angiogenesis is a promising strategy for treating cancer patients. Although numerous endogenous angiogenesis inhibitors have been discovered, the clinical evaluation of these agents has been hindered by high dose requirement
Current Progress in Suicide Gene Therapy for Cancer
β Scribed by Kazuyuki Yazawa; William E. Fisher; F. Charles Brunicardi
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 95 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0364-2313
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Background Mesenchymal stem cells (MSCs) are a promising vehicle for targeted cancer gene therapy because of their potential of tumor tropism. For efficient therapeutic application, we developed retroviral vectorβproducing MSCs that enhance tumor transduction via progeny vector prod
## Abstract ## Background Cytosine deaminase (CD) activates prodrug 5βFC to 5βFU and is used for suicide gene therapy (the CD/5βFC system). __E. coli__ uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage enzyme that directly converts 5βFU into 5βfluorouridine monophosphate and improves